Prof. Inna Slutsky

Tel Aviv University
Department of Physiology and Pharmacology, Sackler Faculty of Medicine

Firing Rate Homeostasis in Neural Circuits: From basic principles to malfunctions

Maintaining average activity level within a set-point range constitutes a fundamental property of central neural circuits. Accumulated evidence suggests that firing rate distributions and their means represent physiological variables regulated by homeostatic systems during sleep-wake cycle in central neural circuits. While intracellular Ca2+ has long been hypothesized as a feedback control signal, the source of Ca2+ and the molecular machinery enabling network-wide homeostatic responses remain largely unknown. I will present our hypothesis and  framework on identifying homeostatic regulators in neural circuits. Next, I will show our new results on the role of mitochondria in the regulation of activity set-points and feedback responses. Finally, I will provide an evidence on state-dependent dysregulation of activity set-points at the presymptomatic disease stage in familial Alzheimer’s models.

Seminar Date & Time:

June 3rd, 2021
14:00 (IST)
Places still available
Notifications and Zoom links are sent to ELSC seminar mailing list, subscribe here.
Providing full name is mandatory for joining Zoom.

Sign here to register for this seminar:

Firing Rate Homeostasis in Neural Circuits: From basic principles to malfunctions